Research Publications Archive - Foundation for Prader-Willi Research | snoRNAs

Roles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation

In the snoRNA host gene SNHG14, 29 consecutive introns each generate SNORD116, and 48 tandem introns encode SNORD115. Loss of SNORD116 expression, but not of SNORD115, is linked to the neurodevelopmental disease Prader-Willi syndrome. SNORD116 and SNORD115 resemble box C/D small nucleolar RNAs...