Small molecule allosteric modulators of the melanocortin-4 receptor for the treatment of Prader-Willi syndrome
Funded Year: 2016There is some data suggesting that one of the systems that regulates appetite and weight in the brain, the melanocortin-4 receptor pathway, may be disrupted in PWS. This study will examine a new class of drugs targeting this pathway, in a mouse model of PWS. The drugs will be tested alone and in combination with other drugs currently being...