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Foundation for Prader-Willi Blog | Research (46)

Clinical trial - modafinil in ADHD

Here is a new study just out in the journal Pediatrics using the new formulation of modafinil for ADHD in children (age 6-17) (a formulation for which Cephalon is seeking FDA approval in children). Modafinil is a "wake promoting" drug that is thought...

Topics: Research

Brain imaging and autism

Brain imaging is really starting to come into its own these days --- the technology is improving and scientists are getting better at interpreting the results. In addition, the NIH is emphasizing support of imagining technology, so hopefully the fiel...

Topics: Research

Narrowing down the genetic region responsible for PWS

Below you'll find the abstract for a newly published paper trying to narrow down exactly which DNA sequences in the PW region of chromosome 15 are responsible for PWS.

Topics: Research

Resource: peer review process

Sense about Science is a UK nonprofit that promotes evidence-based science and public education/discussion regarding the scientific process.

Topics: Research

Genetic characterization of PWS mouse - FPWR supported

Dr. Rob Nicholls has just published another study supported by FPWR. You may recall that his group developed a mouse model of PWS (and Angelman's syndrome if inherited maternally) some years back. We are currently supporting his studies to better cha...

Topics: Research

Refining the genetic region critical for PWS

Below is a link to recently published paper from Dr. Francke's group at Stanford Univ. You might recall that Dr. Francke received an FPWR grant in the first funding cycle (2003), and the work in this publication was supported by those funds.

Topics: Research

Increased number of ghrelin producing cells in PWS

Here is an article in which the authors investigated why people with PWS have high levels of ghrelin in their blood. They wondered if perhaps it had something to do with growth hormone (GH) deficiency, which is common in PWS.

Topics: Research

Comprehensive review of feeding regulation / obesity

Nature Neuroscience is a top notch science journal and this month they have a feature: "Feeding Regulation and Obesity". This 'focus' includes several comprehensive (and pretty hard-core science) reviews on the current understanding of the neurobiolo...

Topics: Research

Obesity drug development - link

Here's a nice summary of (some of the) ongoing obesity drug development strategies:

Topics: Research