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Foundation for Prader-Willi Blog | Research (46)

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Abstracts from the 6th International IPWSO Conference

The 6th Annual International Prader-Willi Syndrome Organization (IPWSO) Conference was held in Romania in June 2007. The research abstracts from the conference are available online at the Asociacin Madrile para el SÃndrome de Prader-Willi (AMSPW) web...
August 27, 2007 Read More

Topics: Research

Fat Fish

Zebrafish are hot - these little fish are all the rage in the research world these days. They develop very quickly (embryo to fish in just a couple of days) and scientists are developing better ways to manipulate their genes and use them to study hum...
July 3, 2007 Read More

Topics: Research

Mice show the way to fix genetic disorders (updated)

It's not often that words such as "rescue of neurological deficits", "therapy for cognitive impairment" and "reversal of neurological defects" are used in the titles of papers studying genetic disorders like Angelman, Down, and Rett syndromes, but a ...
May 10, 2007 Read More

Topics: Research

Psychiatric illness in adults with PWS

One of the most troubling features of PWS is the high risk of mental illness in adults with the syndrome. Although a considerable amount has been written on obsessive-compulsive traits, stubbornness and maladaptive behaviors associated with PWS, less...
February 5, 2007 Read More

Topics: Research

Deletion vs. UPD: 70/30 or 50/50?

Most information about PWS starts out with a brief overview of the genetics of the condition. Deletion of chromosome 15 is listed as the most common cause of PWS, accounting for roughly 70% of cases.
November 21, 2006 Read More

Topics: Research

A genetic basis for autism

Progress in understanding the basis of autism is relevant to PWS for a number of reasons, including the high incidence of autistic behaviors in those with PWS (see, for example: Descheemaeker MJ, et al Pervasive developmental disorders in Prader-Will...
November 7, 2006 Read More

Topics: Research

Nesfatin: a new appetite-control molecule

The number of molecules controlling appetite and body weight continues to grow! A new satiety-inducing molecule, secreted by the hypothalamus, has been identified and named "nesfatin-1" (short for: NEFA/nucleobindin2-encoded satiety- and fat-influenc...
November 7, 2006 Read More

Topics: Research

Obestatin is not elevated in PWS

An article published last year described a new appetite suppressing peptide hormone, obestatin (see previous blog and reference here). One interesting feature about this peptide is that it appears to be derived from the same precursor as ghrelin, the...
October 30, 2006 Read More

Topics: Research

Ghrelin in young kids with PWS- waiting for the storm?

A new paper out in the Journal of Pediatrics looks at Ghrelin levels in young children with Prader-Willi syndrome - Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, Cummings DE. J Pediatrics, 149:199-204, 2006). This study adds to the existing literatur...
September 19, 2006 Read More

Topics: Research

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The Foundation for Prader-Willi Research (federal tax id 31-1763110) is a nonprofit corporation with federal tax exempt status as a public charity under section 501(c)(3).

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