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Foundation for Prader-Willi Blog | Research (45)

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Altering gene expression

Here's a very interesting summary of a research article just published in the journal Cell. The important point here (at least for the sake of this conversation) is not the prostate cancer link - but rather the identification of another protein that ...
May 5, 2006 Read More

Topics: Research

Role for CPT-1 in weight regulation

A new article out in the Journal of Clinical Investigation identifies a new role for the enzyme CPT-1 in weight regulation; the link and a commentary are below. (all JCI commentary and articles are freely available at http://www.jci.org/ if you want ...
May 1, 2006 Read More

Topics: Research

Ghrelin and seizures

Here's an intriguing new study about ghrelin and seizures (go figure), showing that people with epilepsy have significantly higher serum ghrelin levels than healthy individuals. The authors propose that high ghrelin levels may indicate a predispositi...
April 17, 2006 Read More

Topics: Research

Another reason to ditch the tonsils

Kids behave and sleep better after tonsillectomy, University of Michigan study finds Hyperactivity, attention deficit, sleepiness, and ADHD often improved – whether or not sleep studies showed sleep apnea before surgery. http://www.med.umich.edu/op...
April 14, 2006 Read More

Topics: Research

Interesting new paper - Down syndrome

There's a new paper out on Down syndrome that I thought I'd share because it demonstrates several points that I think are relevant to PWS.
January 31, 2006 Read More

Topics: Research

Nutrient sensing in the hypothalamus

Here's a new paper out in Nature Neuroscience that explores the ability of the hypothalamus to sense the nutritional status of the body and modulate hunger in response.
January 27, 2006 Read More

Topics: Research

A role for PWS-snoRNAs, finally!

There's a new paper out in a top journal, Science, on what is may be the first understanding of the underlying molecular basis of features of PWS - The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C -- I've put the link at...
January 17, 2006 Read More

Topics: Research

Why is leptin ignored in obese people and animals?

As many of you know, leptin is the signal released from fat cells that relays a message to the brain that the fat cells are 'full' and it's time to stop eating. It has also been discovered that leptin works directly on the fat cells themselves, decre...
January 8, 2006 Read More

Topics: Research

Mighty muscles

Myostatin normally keeps muscles from growing. Scientist are trying to inhibit myostatin as a therapeutic approach for kids with muscular dystrophy; this strategy has just entered clinical trials using an antibody that sops up the myostatin.
December 13, 2005 Read More

Topics: Research

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